Research – Locomotion Research Labratory

SBHSE Faculty Thurmon Lockhart

Company Lundbeck

Collaborators Dr. Abe Lieberman

Project Title “Effect of L- Dihydoxyphenylserine (L-DOPS, Northera) a Central and Peripheral Norepinephrine Agent on Locomotion, Postural Stability (Balance), and Fall Reduction in Parkinson Disease (PD)”

Description Clinical Trial (NCT02812147): The primary objective of this study is to determine whether treatment with L-DOPS versus placebo in addition to dopaminergic drugs will improve postural stability and reduce falls and/or severity of falls in PD patients.

SBHSE Faculty Thurmon Lockhart

Company Abbott Nutrition

Collaborators Owen Kelly, Sean Garvey

Project Title ANAM1308- Effects of Dietary Supplementation on Dynamic Stability in Community Dwelling Older Adults”

Description Clinical Trial (NCT02806765): Goal of the investigator initiated grant was to assess the treatment effects of Vitamin D (serum 25-hydroxyvitaminD) on dynamic stability and postural stability in community dwelling older adults.

SBHSE Faculty Thurmon Lockhart

Company DSM

Collaborators Volker Elste

Project Title Effects of Vitamin D (serum 25-hydroxyvitaminD) on dynamic stability.

SBHSE Faculty Thurmon Lockhart

Company name Spring Active

Collaborators Jeff Ward

Project Title Quasi-Active Prosthetic Ankle System: NSF 14-603 (SBIR II)

Description In this evaluation, dynamic stability and Socket Comfort Score and Rating of Perceived Exertion will be used to assess performance differences between QPAS and the participant’s passive prosthesis during various walking conditions.

“Effect of Dietary Supplementation on Dynamic Stability” DSM: PI: Thurmon Lockhart (08/01/2015 to 12/31/2017).

ClinicalTrials.gov Identifier : NCT02806765

Sponsor: Arizona State University

Collaborators: Abbott Nutrition/DSM Nutritional Products, Inc./Glencroft Senior Living/Dr. W. Andrew Hodge, MD FACS

Purpose : The purpose of this study is to determine whether specific nutrient supplementation can improve dynamic stability in older adults.

“Effect of L-Dihydoxyphenylserine on Locomotion, Postural Stability, and Fall Risk Reduction in Parkinson Disease,” Lundbeck (9/01/2015 –12/31/2017) PI: Lieberman, Co-PI: Lockhart

ClinicalTrials.gov Identifier : NCT02812147

Sponsor: St. Joseph’s Hospital and Medical Center, Phoenix

Collaborator: Arizona State University, Tempe

Purpose : This research study is being done to determine whether treatment with L- Dihydroxyphenylserine (L-DOPS) versus placebo (an inactive substance that looks like study drug) in addition to other Parkinson Disease (PD) drugs will improve balance, walking, and reduce risk of falls and/or severity of falls in PD subjects. The study is also being done to determine the effectiveness, safety, and tolerability of L-DOPS, and whether it will decrease Freezing of Gait (FOG), improve apathy (generalized disinterest) or show a relationship between apathy and slowed movement and fall risk.

“Non-Intrusive Multi-Patient Fall-Risk Monitoring in Health Care Facilities,” NSF- Information and Intelligent Systems (IIS) and Smart Health and Wellbeing -1065442 and 1065262 (8/01/2011 to 7/31/2016) PI: Lockhart

“Smart and Connected Health Aspiring PI Workshop,” NSF- Information and Intelligent Systems (IIS) and Smart and Connected Health(4/01/2015 to 3/31/2016) PI: Lockhart

“Effects of Vitamin D3 on Muscle function, Stability, Gait, and Activity in Assisted Living Residents,” Abbott Nutrition: PI: Thurmon Lockhart (09/01/2015 to 12/31/2017).