{"id":2851,"date":"2022-10-25T16:12:56","date_gmt":"2022-10-25T23:12:56","guid":{"rendered":"https:\/\/faculty.engineering.asu.edu\/nikkhah\/?post_type=research&p=2851"},"modified":"2026-05-13T13:56:34","modified_gmt":"2026-05-13T20:56:34","slug":"tissue-engineering-organoids-and-stem-cells","status":"publish","type":"research","link":"https:\/\/faculty.engineering.asu.edu\/nikkhah\/research\/tissue-engineering-organoids-and-stem-cells\/","title":{"rendered":"Tissue Engineering, Organoids, and Stem Cells"},"content":{"rendered":"\n

Ex Vivo Microengineered Organoids<\/h2>\n\n\n\n
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Three-dimensional ex vivo<\/em> cellular cultures, engineered through cellular self-assembly under natural extracellular matrix (ECM) cues or through a biomaterial-based directed assembly, have emerged as powerful in vitro<\/em> technologies for a wide range of biomedical applications. The ex vivo<\/em> tissue models imitate one or more physiologically-relevant features and functions of target organs. The on-chip technologies and materials-based organoids have garnered enormous momentum, in the past few years, for their applications in disease modeling, mammalian tissue development, drug screening, and therapy design or even organ replacement.<\/p>\n<\/div><\/div>\n\n\n\n

A. Patino-Guerrero, Ruben P. Wong, V. Kodibagkar, W. Wuqiang, R. Q. Migrino, O. Graudejus, M. Nikkhah<\/strong>*, \u201cDevelopment and Characterization of Isogenic Cardiac Organoids from Human-Induced Pluripotent Stem Cells Under Supplement Starvation Regimen<\/a>\u201d,\u00a0ACS Biomaterials Science & Engineering<\/span><\/em><\/strong>,\u00a09(2), 944-958, (2022).

A. Singh*,\u00a0M. Nikkhah*<\/strong>, N Annabi*, \u201cEditorial: Biomaterials, Cells, and Patho-physiology: Building Better Organoids and On-Chip Technologies<\/a>\u201d,\u00a0Biomaterials<\/u><\/em>,<\/strong>\u00a0198, 1-2, (2019).
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Nanoengineered & Electrically Conductive Biomaterials<\/h2>\n\n\n\n
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The development of advanced biomaterials is a crucial step to enhance the efficacy of tissue engineering strategies for treatment of myocardial infarction. Specific characteristics of biomaterials including electrical conductivity, mechanical robustness and structural integrity need to be tuned to promote the functionalities of cardiac cells. In our lab, we have developed a new class of biomaterial scaffolding comprised of electrically conductive gold nanorods (GNRs) incorporated with photocrosslinkable gelatin-based hydrogel (GelMA) for engineering cardiac tissues with synchronous functionalities. GNRs bridge the electrically insulated matrix of gelatin hydrogel, which leads to enhanced propagation of electrical signal within the cardiac patch and consequently promotes the electromechanical cell-cell coupling. <\/p>\n<\/div>

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M. Jang#, Y. Son#, A. Patino-Guerrero, Y. Singh, K. Neff,\u00a0M. Nikkhah*<\/strong>, and W. Zhu*, \u201cInteraction of Cardiomyocytes from CCND2-overexpressing Human Induced Pluripotent Stem Cells with Electrically Conductive Hydrogels<\/a>\u201d,\u00a0RSC Advances<\/span><\/em><\/strong>,<\/em>\u00a015(27), 21408-21423 (2025).<\/td><\/tr>
H. Esmaeili, A. Patino-Guerrero, R. Nelson, N. Karamanova, T. M. Fisher, W. Zhu, F. Perreault, R. Q. Migrino, M. Nikkhah*,<\/strong> \u201cEngineered Gold and Silica Nanoparticle-incorporated Hydrogel Scaffolds for Human Stem Cell-derived Cardiac Tissue Engineering<\/a>\u201d,\u00a0ACS Biomaterials Science & Engineering<\/span><\/em><\/strong>, 10<\/em>\u00a0(4), 2351-2366, (2024).<\/td><\/tr>

A. Benbuk+, H. Esmaeili+, S. Liu, A. Patino, R. Q. Migrino, J. Chae, M. Nikkhah<\/strong>*, J. Blain Christen*, \u201cPassive and Flexible Wireless Electronics Fabricated on Parylene\/PDMS Substrate for Stimulation of Human Stem Cell-derived Cardiomyocytes<\/a>\u201d,\u00a0ACS Sensors<\/span><\/em><\/strong>, (2022).
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A. Buchberger, H. Saini, K.R. Eliato, A. Zare, R. Merkley, Y. Xu, J. Bernal, R. Ros,\u00a0M.Nikkhah*,\u00a0<\/strong>and N. Stephanopoulos, Reversible Control of Gelatin Hydrogel Stiffness by Using DNA Crosslinkers<\/a>.\u00a0ChemBioChem<\/span><\/strong><\/em>,\u00a022<\/em>(10), pp.1755-1760, (2021).
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Ex Vivo Microengineered Organoids Three-dimensional ex vivo cellular cultures, engineered through cellular self-assembly under natural extracellular matrix (ECM) cues or through a biomaterial-based directed assembly, have emerged as powerful in vitro technologies for a wide range of biomedical applications. The ex vivo tissue models imitate one or more physiologically-relevant features and functions of target organs. The on-chip technologies and materials-based organoids…<\/p>\n","protected":false},"featured_media":0,"parent":0,"menu_order":3,"template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-2851","research","type-research","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/faculty.engineering.asu.edu\/nikkhah\/wp-json\/wp\/v2\/research\/2851","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/faculty.engineering.asu.edu\/nikkhah\/wp-json\/wp\/v2\/research"}],"about":[{"href":"https:\/\/faculty.engineering.asu.edu\/nikkhah\/wp-json\/wp\/v2\/types\/research"}],"version-history":[{"count":0,"href":"https:\/\/faculty.engineering.asu.edu\/nikkhah\/wp-json\/wp\/v2\/research\/2851\/revisions"}],"wp:attachment":[{"href":"https:\/\/faculty.engineering.asu.edu\/nikkhah\/wp-json\/wp\/v2\/media?parent=2851"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}