Google Scholar | Pub Med

Peer-Reviewed Publications


  1. Jayeeta Kolay, Pengfei Zhang, Xinyu Zhou, Zijian Wan, Andy Chieng, and Shaopeng Wang*, Ligand Binding-Induced Cellular Membrane Deformation is Correlated with the Changes in Membrane Stiffness, The Journal of Physical Chemistry B, November 14, 2023,
  2. Pengfei Zhang, Xinyu Zhou, and Shaopeng Wang*, Plasmonic Scattering Microscopy for Label-Free Imaging of Molecular Binding Kinetics: From Single Molecules to Single Cells, Chemistry Method, invited review, 2023, 3, e202200066, DOI: 10.1002/cmtd.202200066.
  3. Xinyu Zhou, Rui Wang, Zijian Wan, Pengfei Zhang*, and Shaopeng Wang*, Multiplexed Protein Detection and Parallel Binding Kinetics Analysis with Label-Free Digital Single-Molecule Counting, Analytical Chemistry, 2023, 95, 2, 1541–1548, DOI: 10.1021/acs.analchem.2c04582.


  1. Xiaoyan Zhou, Guangzhog Ma, Zijian Wan and Shaopeng Wang*, Label-free multi-metric measurement of molecular binding kinetics by electrical modulation of a flexible biolayer, ACS Sensors, 2022, 7, 11, 3461–3469 . Awarded as ACS Editor’s Choice
  2. Pengfei Zhang, Lei Zhou, Rui Wang, Xinyu Zhou, Jiapei Jiang, Zijian Wan, and Shaopeng Wang*, Single Protein Detection and Imaging with Evanescent Scattering Microscopy, Bio-protocol, 2022 Oct 20, 12(20): e4530. DOI: 10.21769/BioProtoc.4530. (invited).
  3. Rui Wang§, Jiapei Jiang,§, Xinyu Zhou, Zijian Wan, Pengfei Zhang*, Shaopeng Wang*, Rapid Regulation of Local Temperature and TRPV1 Ion Channels with Wide-Field Plasmonic Thermal Microscopy, Analytical Chemistry, 2022, Preprint:
  4. Pengfei Zhang, Jiapei Jiang, Xinyu Zhou, Jayeeta Kolay, Rui Wang, Zijian Wan, and Shaopeng Wang*, Label-free imaging and biomarker analysis of exosomes with plasmonic scattering microscopy, Chemical Science, 2022,13, 12760-12768 , DOI: 10.1039/D2SC05191E.
  5. Zijian Wan, Guangzhong Ma, Pengfei Zhang, and Shaopeng Wang*, Single-Protein Identification by Simultaneous Size and Charge Imaging Using Evanescent Scattering Microscopy, ACS Sensors,  2022, 7, 9, 2625–2633 , DOI:10.1021/acssensors.2c01008. NIHMSID: 1835074. PMID: 36000947
  6. Guangzhong Ma, Pengfei Zhang, Xinyu Zhou, Zijian Wan, and Shaopeng Wang*, Label-Free Single-Molecule Pulldown for the Detection of Released Cellular Protein Complexes, ACS Cent. Sci. August 18, 2022, 8, 9, 1272–1281 ,
  7. Fenni Zhang, Manni Mo, Jiapei Jiang, Xinyu Zhou, Michelle McBride, Yunze Yang, Kenta S. Reilly, Thomas E. Grys*, Shelley E. Haydel*, Nongjian Tao, and Shaopeng Wang*, Rapid Detection of Urinary Tract Infection in 10 Minutes by Tracking Multiple Phenotypic Features in a 30-Second Large Volume Scattering Video of Urine Microscopy, ACS Sensors, 2022, 7, 8, 2262–2272 , PMCID: 9465977
  8. Pengfei Zhang, Xinyu Zhou, Jiapei Jiang, Jayeeta Kolay, Rui Wang, Guangzhong Ma, Zijian Wan, Shaopeng Wang*, In Situ Analysis of Membrane-Protein Binding Kinetics and Cell–Surface Adhesion Using Plasmonic Scattering Microscopy, Angewandte Chemie International Ed., 03 August 2022 Oct 17;61(42):e202209469 ,
  9. Pengfei Zhang, Rui Wang, Zijian Wan, Xinyu Zhou, Guangzhong Ma, Jayeeta Kolay, Jiapei Jiang, and Shaopeng Wang*, Label-Free Imaging of Single Proteins and Binding Kinetics Using Total Internal Reflection-Based Evanescent Scattering Microscopy, Chem. 2022, 94, 30, 10781–10787 , Supported by NIH grants R01GM107165. NIHMSID: 1835129
  10. Bo Yao, Yunze Yang, Nanxi Yu, Nongjian Tao, Di Wang*, Shaopeng Wang*, Fenni Zhang*, Label-free quantification of molecular interaction in live red blood cells by tracking nanometer scale membrane fluctuations, Small, 2022, June 19, Supported by NIH grants R01GM124335.
  11. Runli Liang, Yingnan Zhang, Guangzhong Ma and Shaopeng Wang*, Charge-Sensitive Optical Detection of Binding Kinetics between Phage-Displayed Peptide Ligands and Protein Targets, Biosensors 2022 Jun 8;12(6):394. Supported by NIH grants R33CA202834, R44GM139535, and Genentech Inc. grant CLL-016354.
  12. Yunlei Zhao, Guangzhong Ma, and Shaopeng Wang*, Magnetic Nanoparticle Tracking for One-Step Protein Separation and Binding Kinetics Analysis, Electrochem. Soc. 2022, 169, 057509,
  13. Pengfei Zhang, Lei Zhou, Rui Wang, Xinyu Zhou, Jiapei Jiang, Zijian Wan & Shaopeng Wang*, Evanescent scattering imaging of single protein binding kinetics and DNA conformation changes, Nature Communications 2022, 13, 2298 (2022).


  1. Guangzhong Ma, Zijian Wan, Yunze Yang, Wenwen Jing, and Shaopeng Wang*, Three-dimensional tracking of tethered particles for probing nanometer-scale single-molecule dynamics using plasmonic microscope, ACS Sensors, 2021, 6, 11, 4234–4243 , Awarded as ACS Editor’s Choice article. Supported by NIH grants: R33CA235294 and R44GM126720, NIHMSID:1767112
  2. Adaly Garcia, Kinsley Wang, Fatima Bedier, Miriam Benavides, Zijian Wan, Shaopeng Wang and Yixian Wang, Plasmonic Imaging of Electrochemical Reactions at Individual Prussian Blue Nanoparticles, Frontiers in Chemistry, 2021, 9, 718666.
  3. Pengfei Zhang, Xinyu Zhou, Rui Wang, Jiapei Jiang, Zijian Wan, and Shaopeng Wang*, Label-Free Imaging of Nanoscale Displacements and Free-Energy Profiles of Focal Adhesions with Plasmonic Scattering Microscopy, ACS Sensors, 2021, 6, 11, 4244–4254 ,
  4. Pengfei Zhang and Shaopeng Wang*, Real-Time analysis of exosome secretion of single cells with single molecule imaging, BIOCELL, 2021, 45(6): 1449-1451. DOI: 10.32604/biocell.2021.017607
  5. Guangzhong Ma, Runli Liang, Zijian Wan & Shaopeng Wang*, Critical angle reflection imaging for quantification of molecular interactions on glass surface, Nature Communications, volume 12, Article number: 3365 (2021).
  6. Guangzhong Ma, Zijian Wan, Yunze Yang, Wenwen Jing, Shaopeng Wang*, Three-dimensional tracking of tethered particles for probing nanometer-scale single-molecule dynamics using plasmonic microscope, bioRxiv, 2021, 6, 11, 4234–4243 . doi:
  7. Fenni Zhang, Jiapei Jiang, Michelle McBride, Yunze Yang, Manni Mo, Joseph Peterman, Thomas Grys*, Shelley E. Haydel*, Nongjian Tao, and Shaopeng Wang*, Rapid Antimicrobial Susceptibility Testing on Clinical Urine Samples by Video-Based Object Scattering Intensity Detection, Anal. Chem. 2021, 93, 18, 7011–7021. NIHMSID: 1698608.
  8. Pengfei Zhang, Guangzhong Ma, Zijian Wan, and Shaopeng Wang*, Quantification of Single-Molecule Protein Binding Kinetics in Complex Media with Prism-Coupled Plasmonic Scattering Imaging, ACS Sensors, 2021, 6, 3, 1357–1366., PMCID: PMC8046548
  9. Guangzhong Ma, Zijian Wan, Shaopeng Wang*, Simultaneous Imaging of Single Protein Size, Charge, and Binding Using A Protein Oscillation Approach, Bio-Protocol, 2021, DOI: 10.21769/BioProtoc.3934. PMCID: PMC8005875
  10. Stuart Lindsay, Shaopeng Wang, Erica Forzani, Ismael Díez-Pérez, Justin Gooding, The NJ Tao We Knew (editorial), ACS sensors, 2021, 6 (2), 285-289. DOI: 10.1021/acssensors.1c00118
  11. Adaly Garcia, Shaopeng Wang, Nongjian Tao, Xiaonan Shan and Yixian Wang, Plasmonic imaging of oxidation and reduction of single gold nanoparticles and their surface structural dynamics, ACS Sensors, 2021, 6 (2), 502-507, DOI: 10.1021/acssensors.0c02055.
  12. Wen Shi, Yunze Yang, Ming Gao, Jie Wu, Nongjian Tao and Shaopeng Wang*, Optical imaging of electrical and mechanical couplings between cells, ACS Sensors, 2021, 6 (2), 508-512. DOI: 10.1021/acssensors.0c02058. NIHMSID: 1659389, PMID: 33351601
  13. Wenwen Jing, Yi Wang, Chao Chen, Fenni Zhang, Yunze Yang, Guangzhong Ma, Eric H. Yang, Christine Snozek, Nongjian Tao, Shaopeng Wang*, Gradient-based rapid digital immunoassay for high-sensitivity cardiac troponin T (hs-cTnT) detection in 1 µL plasma, ACS sensor, 2021, 6 (2), 399-407, DOI: 1021/acssensors.0c01681. NIHMSID:1646960, PMID: 32985183
  14. Runli Liang, Guangzhong Ma, Wenwen Jing, Yan Wang, Yunze Yang, Nongjian Tao, and Shaopeng Wang,* Charge-Sensitive Optical Detection of Small Molecule Binding Kinetics in Normal Ionic Strength Buffer, ACS Sens., 2021, 6 (2), 364-370, DOI: 10.1021/acssensors.0c01063, Special Issue: Commemorating NJ Tao. NIHMSID:1646963, PMID: 32842724
  15. Fenni Zhang, Shaopeng Wang,* Yunze Yang, Jiapei Jiang, and Nongjian Tao, Imaging Single Bacterial Cells with Electro-optical Impedance Microscopy, ACS Sens., 2021, 6 (2), 348-354, DOI: 10.1021/acssensors.0c00751, Special Issue: Commemorating NJ Tao. NIHMSID:1646965, PMCID: PMC7714712, PMID:32456424


  1. Fenni Zhang, Jiapei Jiang, Michelle McBride, Yunze Yang, Manni Mo, Rafael Iriya, Joseph Peterman, Wenwen Jing, Thomas Grys*, Shelley E. Haydel*, Nongjian Tao*, and Shaopeng Wang*, Direct Antimicrobial Susceptibility Testing on Clinical Urine Samples by Optical Tracking of Single Cell Division Events, Small, 2020, NIHMSID: 1654105
  2. Wenwen Jing, Ashley Hunt, Nongjian Tao, Fenni Zhang* and Shaopeng Wang*, Simultaneous Quantification of Protein Binding Kinetics in Whole Cells with Surface Plasmon Resonance Imaging and Edge Deformation Tracking, Membranes 2020, 10, 247; DOI: 10.3390/membranes10090247
  3. Pengfei Zhang, Guangzhong Ma, Wei Dong, Zijian Wan, Shaopeng Wang* and Nongjian Tao, Plasmonic Scattering Imaging of Single Proteins and Binding Kinetics, Nature Method, 2020, 17, 1010-1017. doi: 10.1038/s41592-020-0947-0;; Behind paper report:
  4. Guangzhong Ma, Zijian Wan, Yunze Yang, Pengfei Zhang, Shaopeng Wang,* Nongjian Tao, Optical imaging of single-protein size, charge mobility and binding, Nature Communications, 2020, 11, 4768. doi: 10.1038/s41467-020-18547-w;; Behind paper report:
  5. Erica S. Forzani, Huixin He, Joshua Hihath, Stuart Lindsay, Reginald M. Penner*, Shaopeng Wang, and Bingqian Xu, Moving Electrons Purposefully through Single Molecules and Nanostructures: A Tribute to the Science of Professor Nongjian Tao (1963–2020), ACS Nano, September 17, 2020, 14, 10, 12291–12312 , NIHMSID:1646969, PMC7718722, PMID:32940998
  6. Wang Y, Yang Y, Chen C, Wang S, Wang H, Jing W, Tao N. One-Step Digital Immunoassay for Rapid and Sensitive Detection of Cardiac Troponin I. ACS Sens. 2020 Apr 24;5(4):1126-1131. doi: 10.1021/acssensors.0c00064. Epub 2020 Mar 30. PubMed PMID: 32180397.
  7. Zhou XL, Yang Y, Wang S, Liu XW. Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging. Angew Chem Int Ed Engl. 2020/1/27, 59(5), 1776-1785. DOI: 10.1002/anie.201908806. PubMed PMID: 31531917. NIHMSID: 1068747
  8. Rafael Iriya, Wenwen Jing, Karan Syal, Manni Mo, Chao Chen, Hui Yu, Shelley E Haydel, Shaopeng Wang, Nongjian Tao, Rapid antibiotic susceptibility testing based on bacterial motion patterns with long short-term memory neural networks, IEEE Sensors Journal, vol. 20, no. 9, pp. 4940-4950, May 1, 2020. NIHMS1588088, PMCID: PMC7241544.


  1. G Ma, X Shan, S Wang, N Tao, Quantifying Ligand-Protein Binding Kinetics with Self-Assembled Nano-Oscillators, Anal. Chem. 2019, 91(21), 14149-14156. DOI: 10.1021/acs.analchem.9b04195. PMCID: PMC6995402. 
  2. F Zhang, Y Guan, Y Yang, A Hunt, S Wang, HY Chen, N Tao, Optical tracking of nanometer-scale cellular membrane deformation associated with single vesicle release, 2019, ACS sensors, 4 (8), 2205-2212. DOI: 10.1021/acssensors.9b01201. PMCID: PMC7007815. NIHMSID: 1068592.
  3. W Jing, Y Wang, Y Yang, Y Wang, G Ma, S Wang, N Tao, Time-resolved digital immunoassay for rapid and sensitive quantitation of procalcitonin with plasmonic imaging, 2019, ACS nano 13 (8), 8609-8617. DOI: 10.1021/acsnano.9b02771. PMCID: PMC7008466. NIHMSID: 1068734
  4. M Mo, Y Yang, F Zhang, W Jing, R Iriya, J Popovich, S Wang, T Grys, S. E. Haydel, N. Tao, Rapid Antimicrobial Susceptibility Testing of Patient Urine Samples using Large Volume Free-Solution Light Scattering Microscopy, Analytical chemistry, 2019, 91 (15), 10164-10171. DOI: 10.1021/acs.analchem.9b02174. PMCID: PMC7003966 
  5. Y Yang, X Liu, S Wang, N Tao, Plasmonic imaging of subcellular electromechanical deformation in mammalian cells, Journal of Biomedical Optics, 2019, 24 (6), 066007. PMCID: PMC6586072 DOI: 10.1117/1.JBO.24.6.066007
  6. Guan-Da Syu, Shih-Chin Wang, Guangzhong Ma, Shuang Liu, Donna Pearce, Atish Prakash, Brandon Henson, Lien-Chun Weng, Devlina Ghosh, Pedro Ramos, Daniel Eichinger, Ignacio Pino, Xinzhong Dong, Jie Xiao, Shaopeng Wang, Nongjian Tao, Kwang Sik Kim, Prashant J. Desai & Heng Zhu, Development and application of a high-content virion display human GPCR array, Nature Communications (2019)10:1997. DOI: 10.1038/s41467-019-09938-9
  7. Guangzhong Ma, Hao Zhu, Zijian Wan, Yunze Yang, Shaopeng Wang, Nongjian Tao, Optical imaging of single protein size, charge, mobility, binding and conformational change, bioRxiv, 2019/1/1, p505404.


  1. Ma, Guangzhong; Syu, Guan-Da; Shan, Xiaonan; Henson, Brandon; Wang, Shaopeng; Desai, Prashant; Zhu, Heng; Tao, Nongjian, Measuring ligand binding kinetics to membrane proteins using virion nano-oscillators, J. Am. Chem. Soc., 2018, Sep 12;140(36): 11495 – 11501. doi: 10.1021/jacs.8b07461. PubMed PMID: 30114365. NIHMSID: 994023
  2. Hui Yu, Wenwen Jing, Rafael Iriya, Yunze Yang, Karan Syal, Manni Mo, Thomas E Grys, Shelley E Haydel, Shaopeng Wang, Nongjian Tao, Phenotypic antimicrobial susceptibility testing with deep learning video microscopy, Anal. Chem., 2018, 90 (10), pp 6314–6322, DOI: 10.1021/acs.analchem.8b01128
  3. Yang, X.W. Liu, H. Wang, H. Yu, Y. Guan, S. Wang, and N. Tao, Imaging Action Potential in Single Mammalian Neurons by Tracking the Accompanying Sub-Nanometer Mechanical Motion, ACS Nano, 2018, 12, 4186-4193. DOI: 10.1021/acsnano.8b0086723, PMCID: PMC6141446. Preprint deposited in:
  4. Yu H, Yang Y, Yang Y, Zhang F, Wang S, Tao N. Tracking fast cellular membrane dynamics with sub-nm accuracy in the normal direction. Nanoscale. 2018 Mar 15; 10(11): 5133–5139. . doi: 10.1039/c7nr09483c. PubMed PMID: 29488990. PMCIF: PMC5854544.
  5. Fenni Zhang, Wenwen Jing, Ashley Hunt, Hui Yu, Yunze Yang, Shaopeng Wang, Hong-Yuan Chen, and Nongjian Tao, Label-Free Quantification of Small Molecule Binding to Membrane Proteins on Single Cells by Tracking Nanometer-Scale Cellular Membrane Deformation, ACS Nano, 2018 Feb 27; 12(2): 2056–2064. , DOI: 10.1021/acsnano.8b00235. PubMed PMID: 29397682, PMCID: PMC5851003..


  1. Iriya R, Syal K, Jing W, Mo M, Yu H, Haydel SE, Wang S, Tao N. Real-time detection of antibiotic activity by measuring nanometer-scale bacterial deformation. J Biomed Opt. 2017 Dec;22(12):1-9. doi: 10.1117/1.JBO.22.12.126002. PubMed PMID: 29235272.
  2. Syal, Karan; Shen, Simon; Yang, Yunze; Wang, Shaopeng; Haydel, Shelley; Tao, Nongjian, Rapid antibiotic susceptibility testing of uropathogenic E. coli by tracking sub-micron scale motion of single bacterial cells, 2017, ACS Sensors, 2017, 2 (8), pp 1231–1239. DOI: 10.1021/acssensors.7b00392
  3. Liu, X.-W., Yang, Y., Wang, W., Wang, S., Gao, M., Wu, J. and Tao, N. Plasmonic-Based Electrochemical Impedance Imaging of Electrical Activities in Single Cells. 2017, Angew. Chem. Int. Ed.. 56, 8855, doi:10.1002/anie.201703033, PubMed PMID: 28504338, PMCID: PMC5837822.
  4. H Yu, X Shan, S Wang, N Tao, Achieving high spatial resolution surface plasmon resonance microscopy with image reconstruction, Anal. Chem., 2017, 89 (5), pp 2704–2707. DOI: 10.1021/acs.analchem.6b05049.
  5. Y Wang, X Shan, H Wang, S Wang, N Tao, Plasmonic imaging of surface electrochemical reactions of single gold nanowires, J. Am. Chem. Soc., 2017, 139 (4), pp 1376–1379. DOI: 10.1021/jacs.6b10693.
  6. K Syal, M Mo, H Yu, R Iriya, W Jing, G Sui, S Wang, TE Grys, SE Haydel, N Tao, Current and emerging techniques for antibiotic susceptibility tests, Theranostics 2017, 7 (7), 1795-1805


  1. Jin Lu, Yunze Yang, Wei Wang, Jinghong Li, Nongjian Tao*, Shaopeng Wang*, Label-free imaging of histamine mediated G protein-coupled receptors activation in live cells, Anal. Chem. 2016, 88, 11498−11503. DOI: 10.1021/acs.analchem.6b02677. PMCID# PMC5144837 (Open access)
  2. Guangzhong Ma, Yan Guan, Shaopeng Wang*, Han Xu*, and Nongjian Tao*, Study Small Molecule-Membrane Protein Binding Kinetics with Nanodisc and Charge Sensitive Optical Detection, Anal. Chem. 2016, 88, 2375-2379, DOI: 10.1021/acs.analchem.5b04366. NIHMS836629, PubMed # 26752355
  3. Yixian Wang, Xiaonan Shan, Shaopeng Wang, and Nongjian Tao, Imaging Local Electric Field Distribution by Plasmonic Impedance Microscopy, Anal. Chem. 2016, 88, 1547-1552, DOI: 10.1021/acs.analchem.5b04382
  4. Karan Syal, Rafael Iriya, Yunze Yang, Hui Yu, Shaopeng Wang, Shelley E Haydel, Hong-Yuan Chen, and Nongjian Tao, Antimicrobial Susceptibility Test with Plasmonic Imaging and Tracking of Single Bacterial Motions on Nanometer Scale, ACS Nano, 2016, 10(1), 845-852. DOI: 10.1021/acsnano.5b05944


  1. Zixuan Chen, Xiaonan Shan, Yan Guan, Shaopeng Wang, Jun-Jie Zhu, and Nongjian Tao, Imaging Local Heating and Thermal Diffusion of Nanomaterials with Plasmonic Thermal Microscopy, ACS Nano, 2015, 9 (12), pp 11574–11581 DOI: 10.1021/acsnano.5b05306
  2. Simon Shen, Karan Syal, Nongjian Tao* and Shaopeng Wang*, Note: An automated image analysis method for high-throughput classification of surface-bound bacterial cell motions, Review of Scientific Instrument, 2015, 86, 126104. DOI: 10.1063/1.4937479
  3. Linliang Yin, Shaopeng Wang*, Xiaonan Shan, Shengtao Zhang, Nongjian Tao*, Quantification of protein interaction kinetics in a micro droplet, Review of Scientific Instruments, 2015, 86, 114101. DOI: 10.1063/1.4934802. PMCID: PMC4636506. (RSI editor’s Picks, Featured Article, Cover Article)
  4. Xiaonan Shan, Shan Chen, Hui Wang, Zixuan Chen, Yan Guan, Yixian Wang, Shaopeng Wang, Hong-Yuan Chen, Nongjian Tao, Mapping Local Quantum Capacitance and Charged Impurities in Graphene via Plasmonic Impedance Imaging, Advanced Materials, 2015, 27(40), 6213-6219, DOI: 10.1002/adma.201502822
  5. Yan Guan, Xiaonan Shan, Fenni Zhang, Shaopeng Wang, Hong-Yuan Chen, Nongjian Tao, Kinetics of small molecule interactions with membrane proteins in single cells measured with mechanical amplification, Science Advances, 2015, 1, e1500633. DOI: 10.1126/sciadv.1500633 
  6. Fenni Zhang, Shaopeng Wang*, Linliang Yin, Yunze Yang, Yan Guan, Wei Wang, Han Xu and Nongjian Tao*, Quantification of Epidermal Growth Factor Receptor Expression Level and Binding Kinetics on Cell Surfaces by Surface Plasmon Resonance Imaging, Anal. Chem. 2015, 87 (19), 9960-9965. DOI: 10.1021/acs.analchem.5b02572. PMID: 26368334, NIHMSID 777521, PMCID: PMC4836855
  7. Linliang Yin, Yunze Yang, Shaopeng Wang, Wei Wang, Shengtao Zhang, Nongjian Tao, Measuring the binding kinetics of antibody-conjugated gold nanoparticles with intact cells, Small, 11(31), 3782-3788. Doi:10.1002/smll.201500112. PMCID: PMC4552349. PMID: 25865036
  8. Yunze Yang,  Hui Yu,  Xiaonan Shan, Wei Wang, Xianwei Liu, Shaopeng Wang, and Nongjian Tao, Label-Free Tracking of Single Organelle Transportation in Cells with Nanometer Precision Using a Plasmonic Imaging Technique, Small11(24), 2878-2884, 2015, DOI: 10.1002/smll.201403016. PMCID: PMC4474744
  9. Linliang Yin, Wei Wang, Shaopeng Wang, Fenni Zhang, Shengtao Zhang, Nongjian Tao, How does fluorescent labeling affect the binding kinetics of proteins with intact cells? Biosensors and Bioelectronics, 2015, 66, 412-416. DOI: 10.1016/j.bios.2014.11.036. PMID: 25486538. NIHMSID 647485, PMCID: PMC4836836.
  10. Karan Syal, Wei Wang, Xiaonan Shan, Shaopeng Wang, Hong-Yuan Chen, Nongjian Tao, Plasmonic imaging of protein interactions with single bacterial cells, Biosens. Bioelectron., 2015, 63, 131-137. DOI: 10.1016/j.bios.2014.06.069.
  11. Yixian Wang, Xiaonan Shan, Fengjuan Cui, Jinghong Li, Shaopeng Wang, Nongjian Tao, Electrochemical reactions in sub-femtoliter-droplets studied with plasmonics-based electrochemical current microscopy, Analytical Chemistry, 2015, 87(1), 494-498, DOI: 10.1021/ac5036692.


  1. Wei Wang, Linliang Yin, Laura Gonzalez-Malerva, Shaopeng Wang, Xiaobo Yu, Seron Eaton, Shengtao Zhang, Hong-Yuan Chen, Joshua LaBaer, Nongjian Tao, In situ drug-receptor binding kinetics in single cells: a quantitative label-free study of anti-tumor drug resistance, Scientific Reports, 2014, 4, doi:10.1038/srep06609. PMCID: PMC4196117
  2. Wenbin Liang, Shaopeng Wang*, Fernanda Festa, Peter Wiktor, Wei Wang, Mitchell Magee‖, Joshua LaBaer*, Nongjian Tao*, Measure Small Molecule Binding Kinetics on Protein Microarray by Plasmonic-based Electrochemical Impedance Imaging, Analytical Chemistry, 2014, 86 (19), 9860–9865. DOI: 10.1021/ac5024556, PMCID# PMC4188269.
  3. Hui Yu, Xiaonan Shan, Shaopeng Wang, Hong-Yuan Chen, Nongjian Tao, Molecular scale origin of surface plasmon resonance biosensors, Analytical Chemistry, 2014, 86 (18), 8992-8997. DOI: 10.1021/ac501363z
  4. Xiaonan Shan, Yimin Fang, Shaopeng Wang, Yan Guan, Jongyuan Chen and Nongjian Tao, Detection of charges and molecules with self-assembled nano-oscillators, Nano Lett., 2014, 14 (7), 4151–4157. DOI: 10.1021/nl501805e. 
  5. Hui Yu, Xiaonan Shan, Shaopeng Wang, Jongyuan Chen and Nongjian Tao, Plasmonic Imaging and Detection of Single DNA Molecules, ACS Nano, 2014, (4), 3427–3433. DOI: 10.1021/nn4062885.
  6. Yan Guan, Xiaonan Shan, Shaopeng Wang, Peiming Zhang, and Nongjian Tao, Detection of molecular binding via charge-induced mechanical response of optical fibers, Chemical Science, 2014, (11), 4375-4381. DOI: 10.1039/C4SC01188K. NIHMSID 836629


  1. Christopher MacGriff, Ly Nguyen, Shaopeng Wang,* Nongjian Tao, Note: Four-port microfluidic flow-cell with instant sample switching, Review of Scientific Instruments, 2013, 84(10), 106110. DOI: 10.1063/1.4826359. PMCID: PMC4108724. 
  2. Christopher MacGriff, Shaopeng Wang*, Peter Wiktor, Wei Wang, Xiaonan Shan, Nongjian Tao, Charge-based Detection of Small Molecules by Plasmonic-based Electrochemical Impedance Microscopy, Analytical Chemistry85 (14), 6682–6687, 2013. DOI: 10.1021/ac400475z. 


  1. Xiaonan Shan, Ismael Díez-Pérez, Luojia Wang, Peter Wiktor, Ying Gu, Lihua Zhang, Wei Wang, Jin Lu, Shaopeng Wang, Qihuang Gong, Jinghong Li & Nongjian Tao, Imaging the electrocatalytic activity of single nanoparticles, Nature Nanotechnology, 2012, 7, 668–672. doi:10.1038/nnano.2012.134.
  2. Wei Wang, Yunze Yang, Shaopeng Wang, Vinay J Nagaraj, Qiang Liu, Jie Wu and Nongjian Tao, Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells, Nature Chemistry, 2012, 4(10), 846-853. DOI:10.1038/nchem.1434. (PMC # 3660014 NIHMSID # 468566)
  3. Wang, Wei; Wang, Shaopeng; Liu, Qiang; Wu, Jie; Tao, Nongjian, Mapping Single-Cell–Substrate Interactions by Surface Plasmon Resonance Microscopy, Langmuir, 2012, 28(37), 13373-13379, DOI: 10.1021/la301712h, PMCID: PMC3660850.
  4. Jin Lu, Wei Wang, Shaopeng Wang, Xiaonan Shan, Jinghong Li, Nongjian Tao, “Plasmonic-Based Electrochemical Impedance Spectroscopy: Application to Molecular Binding” Analytical Chemistry, Anal. Chem., 2012, 84 (1), pp 327–333, DOI: 10.1021/ac202634h, NIHMSID: 344470. PMCID: PMC3299414.


  1. Shan, Xiaonan; Wang, Shaopeng; Wang, Wei; Tao, Nongjian, Plasmonic-based Imaging of Local Square Wave Voltammetry, Analytical Chemistry, Anal. Chem., 2011, 83 (19), pp 7394–7399, DOI: 10.1021/ac201392r, PMCID: PMC3288114.
  2. Rinosh Joshua Mani, Roman G. Dye, Timothy A. Snider, Shaopeng Wang, Kenneth D. Clinkenbeard, bi-cell surface plasmon resonance detection of aptamer mediated thrombin capture in serum, Biosensors and Bioelectronics, 26 (2011) 4832– 4836. 
  3. Wei Wang, Kyle Foley, Xiaonan Shan, Shaopeng Wang, Seron Eaton, Vinay J Nagaraj, Peter Wiktor, Urmez Patel, and Nongjian Tao, Single cells and intracellular processes studied by a plasmonic-based electrochemical impedance microscopy, Nature Chemistry, 3, 249–255, (2011), doi:10.1038/nchem.961, NIHMSID: NIHMS358337, PMCID: PMC3309525.


  1. Xiaonan Shan, Shaopeng Wang and Nongjian Tao, Study of single particle charge and Brownian motions with surface plasmon resonance, Applied Physic Letters, 97, 223703, 2010, PMCID: 3009754
  2. Wang, X. Shan, U. Patel, X. Huang, J. Lu, J. Li, NJ Tao, Label-free imaging, detection and mass measurement of single viruses by Surface Plasmon Resonance, Proc Natl Acad Sci U S A, 2010, 107 (37), 16028-16032, PMCID: 2941305.
  3. Shan, U. Patel, S. Wang, R. Iglesias, NJ. Tao, Imaging Local Electrochemical Current Via Surface Plasmon Resonance, Science, 2010, 327, 1363.
  4. Wang, X. Huang, X. Shan, K. J. Foley, NJ. Tao, Electrochemical Surface Plasmon Resonance: Basic Formalism and Experimental Validation, Analytical Chemistry, 2010, 82(3), 935-941. DOI: 10.1021/ac902178f


  1. X. Huang, S. Wang, X. Shan, X. Chang, NJ Tao, Flow-through Electrochemical Surface Plasmon Resonance: Detection of intermediate reaction products, Journal of Electroanalytical Chemistry 649 (2010) 37–41, DOI:10.1016/j.jelechem.2009.12.027
  2. X. Shan, X. Huang, K. J. Foley, P. Zhang, K. Chen, S. Wang, and NJ. Tao, Measuring Surface Charge Density and Particle Height Using Surface Plasmon Resonance Technique, Analytical Chemistry, 2010, 82(1), 234-240. DOI: 10.1021/ac901816z
  3. S. Wang,* A. Ramachandran, S. J. Ja, Integrated Microring-Resonator Biosensors for Monitoring of Cell Growth and Detection of Toxic Chemicals in Water, Biosensors and Bioelectronics, 2009, 24, 3061–3066. DOI: 10.1016/j.bios.2009.03.027.
  4. J. E. Nichols, J. Cortiella, J. Lee, J. A. Niles, M. Cuddihy, S. Wang, A. Cantu, R. Mlcak, E. Valdivia, R. Yancy, J. Bielitzki, M. L. McClure, N. A. Kotov. In vitro analog of human bone marrow from 3D scaffolds with biomimetic inverted colloidal crystal geometry, Biomaterials, 30 (6), p.1071-1079, Feb 2009.


  1. A. Ramachandran, S. Wang, J. Clarke, S. J. Ja, D. Goad, L. Wald, E. M. Flood, E. Knobbe, J. V. Hryniewicz, S. T. Chu, D. Gill, W. Chen, O. King, and B. E. Little, A Universal Biosensing Platform Based on Optical Micro-Ring Resonators, Biosensors and Bioelectronics, 2008, 23, 939–944. DOI:10.1016/j.bios.2007.09.007.
  2. W. Chen, S. L. Westcott, S. Wang, and Y. Liu, Dose dependent x-ray luminescence in MgF2:Eu2+, Mn2+ phosphors, J. Appl. Phys. 103, 113103 (2008); DOI:10.1063/1.2937084.
  3. Y. Zhang, W. Chen, S. Wang, Y. Liu, L. Liu, C. Pope. Phototoxicity of zinc oxide nanoparticle conjugates in human ovarian cancer NIH: OVCAR-3 cells. J. Biomed. Nanotech. 2008, 4, 432-438.
  4. Y. Liu, W. Chen, S. Wang, A. Joly, S. Westcott, and B. Woo, X-ray Luminescence of LaF3:Tb and LaF3:Ce,Tb Water Soluble Nanoparticles, Journal of Applied Physics, 2008, 103, 063105. DOI: 10.1063/1.2890148.
  5. Y. Liu, Y. Zhang, S. Wang, C. Pope, and W. Chen, Optical behaviors of ZnO-porphyrin conjugates and their potential applications for cancer treatment, Applied Physics Letters, 2008, 92, 143901. DOI: 10.1063/1.2908211.
  6. Y. Liu, W. Chen, S. Wang, A. Joly, Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Photodynamic Activation, Applied Physics Letter, 2008, 92, 043901. Note: This article was selected for the February 11, 2008 issue of Virtual Journal of Nanoscale Science & Technology (, and for the February 1, 2008 issue of Virtual Journal of Biological Physics Research (


  1. Y. Liu, S. Wang, J. Krouse, N. A. Kotov, M. Eghtedari, G. Vargas, and M. Motamedi, Rapid Aqueous Photo-polymerization Route to Polymer and Polymer-composite Hydrogel 3D Inverted Colloidal Crystal Scaffolds, Journal of Biomedical Materials Research: part A, 2007, DOI: 10.1002/jbm.a.31199.
  2. Y. Liu and S. Wang,* 3D Inverted Opal Hydrogel Scaffolds with Oxygen Sensing Capability, Colloids and Surfaces B: Biointerfaces, 2007, 58(1), 8-13.
  3. S. Wang,* E. S. Forzani, NJ. Tao, Detection of Heavy Metal Ions in Water by High Resolution Surface Plasmon Resonance Spectroscopy Combined with Anodic Stripping Voltammetry, Analytical Chemistry, 2007, 79(12), 4427-4432, DOI: 10.1021/ac0621773.
  4. A. G. Joly, W. Chen, J. Zhang, and S. Wang, Electronic Energy Relaxation and Luminescence Decay Dynamics of Eu3+ in Zn2SiO4:Eu3+ Phosphors, Journal of Luminescence, 2007, 126, 491–496.


  1. F. Su, B. Ma, K. Ding, G. Lia, S. Wang, W. Chen, A. G. Joly, and D. E. McCready, Luminescence Temperature and Pressure Studies of Zn2SiO4 Phosphors doped with Mn2+ and Eu3+ ions, Journal of Luminescence, 2006, 116, 117–126.


  1. S. Sachin, S. Wang, and N. A. Kotov, Cell Distribution Profiles in Three-Dimensional Scaffolds with Inverted Colloidal Crystal Geometry: Modeling and Experimental Investigations, Small, 2005, 1(12), 1208-1214.
  2. W. Chen, J.-O. Bovin, S. Wang, A. G. Joly, Y. Wang, and P. M. A. Sherwood, Fabrication and Luminescence of ZnS:Mn2+Nanoflowers, Journal of Nanoscience and Nanotechnology, 2005, 5, 1-14.
  3. W. Chen, S. Wang, S. L. Westcott, J. Zhang, K. Dou, A. G. Joly, and D. E. McCready, Structure and Luminescence of BaFBr:Eu(2+) and BaFBr:Eu(2+), Tb(3+) Phosphors and Thin Films, Journal of Applied Physics, 2005, 97, 083506-083514.
  4. Y. Liu, S. Wang, and N. A. Kotov, A Floating Self-Assembly Route to Colloidal Crystal Templates for 3D Cell Scaffolds, Chemistry of Materials, 2005, 17(20); 4918-4924 (DOI: 10.1021/cm048050g).
  5. Y. Zhang, S. Wang, M. Eghtedari, M. Motamedi and N. A. Kotov, Inverted Colloidal Crytal Hydrogel Matrices as Three-Dimensional (3D) Cell Scaffolds, Advanced Functional Materials, 2005, 15, 728-731.


  1. N. A. Kotov, Y. Liu, S. Wang, C. Cumming, M. Eghtedari, G. Vargas, M. Motamedi, J. Nichols, J. Cortiella, Inverted Colloidal Crytals as 3D Cell Scaffolds, Langmuir, 2004, 2019, 7887 – 7892 (DOI: 10.1021/la049958o, cover article).
  2. W. Chen, J-O. Bovin, A. G. Joly, S. Wang, F. Su and G. Li, Full-Color from In2S3 and In2S3:Eu3+ Nanoparticles, Journal of Physical Chemistry B, 2004; 108; 11927-11934.


  1. W. Chen, A. G. Joly, J-O. Malm, J.-O. Bovin, and S. Wang, Full-Color Emission and Temperature Dependence of the Luminescence in Poly-P-phenylene ethynylene-ZnS/Mn2+ Composite Particles, Journal of Physical Chemistry B, 2003, 107(27), 6544-6551.


  1. S. Wang, S. Westcott, and W. Chen, Nanoparticle Luminescence Thermometry, Journal of Physical Chemistry B, 2002, 106, 11203-11209.
  2. S. Wang, N. Mamedova, N. A. Kotov, W. Chen, and J. Studer, Antigen/Antibody Immunocomplex from CdTe Nanoparticle Bioconjugates, Nano Letter, 2002, 2(8), 817-822. Cited 700+.


  1. S. Wang, S. Boussaad, and N. J. Tao, Surface Plasmon Resonance Enhanced Absorption Spectroscopy, Review of Scientific Instruments, 2001, 72, 3055-3060.


  1. S. Wang, S. Boussaad, S. Wong, and N. J. Tao, High-sensitivity Stark Spectroscopy of Organic dsorbates Based on Detection of Surface Plasmon Resonance, Analytical Chemistry, 2000, 72, 4003-4008.
  2. S. Wang, Q. Zhang, P. K. Datta, R. E. Gawley, and R. M. Leblanc, Amphiphilic Anthracyl Crown Ether – a Langmuir and Langmuir-Schaefer Films Study, Langmuir, 2000, 16(10), 4607-4612.
  3. S. Wang, R. Lunn, M. P. Krafft, and R. M. Leblanc, One and a Half Layer? Mixed Langmuir Monolayer of 10,12-pentacosadiynoic Acid and a Semi-fluorinated Tetracosane, Langmuir, 2000, 16(6); 2882-2886.


  1. S. Wang and R. M. Leblanc, Molecular Recognition of Concanavalin A on Mannoside Lipid Monolayer at Air/Water Interface, Biochimica et Biophysica Acta – Biomembranes, 1999, 1419, 307-312. 
  2. Q. Huo, S. Wang, A. Pisseloup, D. Verma, and R. M. Leblanc, Unusual Chromatic Properties Observed from Polymerized Dipeptide Diacetylenes, Chemical Communications, 1999, 1601-1602. 
  3. S. Wang, J. Ramirez, P. G. Wang, and R. M. Leblanc, Surface Chemistry, Topography and Spectroscopy of Mixed-monolayer of 10,12-pentacosadiynoic Acid and its Mannoside Derivative at the Air-water Interface, Langmuir, 1999, 15, 5623-5629. 
  4. R. E. Gawley, Q. Zhang, P. I. Higgs, S. Wang, and R. M. Leblanc, Anthracylmythyl Crown Ethers as Fluorescence Sensors of Saxitoxin, Tetrahedron Letters, 1999, 5461-5464. Corrigendum, p6135.


  1. S. Wang, S. Vidon, and R. M. Leblanc, Chemical and Photochemical Dual Polymerization in a Mixed Langmuir Monolayer of Diacetylene Derivatives and Octadecyltrimethoxysilane, Journal of Colloid and Interface Science, 1998, 207, 303-308. 
  2. Y. J. Li; Y. Fan; X. G. Ren; L. G. Zhang; D. P. Jiang; A. D. Lu; S. Wang, and R. M. Leblanc, Synthesis of a Substituted Phthalocyaninato-Polysiloxane and its Langmuir-Blodgett Films, Journal of Porphyrins and Phthalocyanines, 1998, 2, 1-4. 
  3. S. Wang, R. M. Leblanc, F. Arias, and L. Echegoyen, Study of Langmuir Monolayers of Crown-ether C60 Derivatives and their Interaction with Different Subphase Ions, Thin Solid Film, 1998, 327, 141-144. 
  4. F. Cardullo, F. Diederich, L. Echegoyen, T. Habicher, N. Jayaraman, R. M. Leblanc, J. F. Stoddart, and S. Wang, Stable Langmuir and Langmuir-Blodgett films of Fullerene-Glycodendron Conjugates, Langmuir, 1998, 14, 1955-1959. 


  1. L. Dziri, S. Boussaad, S. Wang and R. M. Leblanc, Surface Topography of Acetylcholinesterase in Langmuir and Langmuir-Blodgett Films, The Journal of Physical Chemistry, 1997, 101(34), 6741-6748. 
  2. S. Wang, Y. Li, L. Shao, J. Ramirez, P. G. Wang, and R. M. Leblanc, Excess Free Energies of Interaction between 10,12-pentacosadiynoic Acid (PDA) and its Mannoside Derivative (MPDA). A Mixed-Monolayer Study, Langmuir, 1997, 13, 1677-1681.
  3. S. Wang, R. M. Leblanc, F. Arias, and L. Echegoyen, Surface and Optical Properties of Langmuir and LB films of a Crown-ether C60 Derivative, Langmuir, 1997, 13, 1672-1676. 


  1. Z. Liu, H. Qin, C. Xiao, C. Wen, S. Wang, and S. Sui, Specific Binding of Avidin to Biotin Containing Lipid Lamella Surfaces Studied with Monolayers and Liposomes. European Biophysics Journal, 1995, 24, 31-38. 


  1. S. Wang and S. Sui, In Situ Observation of Lipid Monolayers at Air/Water Interface by Micro-Fluorescence Film Balance, Progress in Natural Science 《自然科学进展》, 1994, 4(4), 410-416.
  2. S. Wang, C. Wen and S. Sui, Influence of Flexibility of Receptors on Specific Binding of Avidin onto Lipid Membrane, Progress in Natural Science 《自然科学进展》, 1994, 4(3), 375-380.
  3. Z. Liu, S. Wang, C. Wen, and S. Sui, Interaction between Avidin and Membrane Bond Model Receptor, Science in China《中国科学》Series B, Chemistry, Life Sciences & Earth Sciences, 1994, 24(11), 1162-1170.


  1. S. Wang and S. Sui, Interaction of Vesicles with Phospholipid Monolayer, Acta Biophysica Sinica 《生物物理学报》, 1992, 8(1), 148-153. 
  2. S. Sui and S. Wang, Fusion of Phospholipid Vesicles with Langmuir Lipid Monolayer, Thin Solid Films, 1992, 210, 57-59. 


  1. S. Sui, H. Wu, and S. Wang, Langmuir-Blodgett FilmBalance, Experimental Technique and Management《实验技术与管理》, 1991, 8(5), 28-31. 
  2. S. Wang and S. Sui, Study on the Properties of Cholesterol-Containing Phospholipid Monolayers (LB Film), Acta Biophysica Sinica《生物物理学报》, 1991, 7(3), 328-334. 
  3. S. Sui and S. Wang, Langmuir-Blodgett Film and its Application in Biology (review), Progress in Biological Engineering《生物工程进展》, 1991, 11(1), 1-10. 

Book Chapters

  1. Wang*, G. Ma, R. Liang, N. Tao (2022) Charge Sensitive Optical Detection for Measurement of Small-Molecule Binding Kinetics. In: Ossandon M.R., Baker H., Rasooly A. (eds) Biomedical Engineering Technologies. Methods in Molecular Biology, vol 2393, 315-328. Humana, New York, NY.
  2. S. Wang and N. A. Kotov, book chapter: Nanoparticle Labeled Antibodies and Antigens, Dekker Encyclopedia of Nanoscience and Nanotechnology, Editors: James A. Schwarz, Cristian I. Contescu and Karol Putyera, Marcel Dekker, Inc., New York, 2004, Vol 1, No. 1, 1647-1653 (ISBN: 0-8247-5055-1, 0-8247-5046-2).
  3. W. Chen, A.G. Joly, and S. Wang, book chapter: Luminescence of Semiconductor Nanoparticles, Encyclopedia of Nanoscience and Nanotechnology, American Scientific Publishers, Los Angeles, 2004, Vol. 4, 689-718 (ISBN: 1-58883-001-2).
  4. S. Wang, S. Boussaad, and N. J. Tao, book chapter: Surface Plasmon Resonance Spectroscopy: Applications in Protein Adsorption and Electrochemistry, in Biomolecular Films: Design, Function, and Applications, Editor: Jim Rusling, Marcel Dekker, Inc., New York, 2003, 213-252 (ISBN: 0-8247-0899-7).