Full Project Title: Effect of L- Dihydoxyphenylserine (L-DOPS, Northera) a Central and Peripheral Norepinephrine Agent on Locomotion, Postural Stability (Balance), and Fall Reduction in Parkinson Disease (PD)

ClinicalTrials.gov Identifier : NCT02812147

Clinical Trial (NCT02812147):  The primary objective of this study is to determine whether treatment with L-DOPS versus placebo in addition to dopaminergic drugs will improve postural stability and reduce falls and/or severity of falls in PD patients.

Purpose : This research study is being done to determine whether treatment with L- Dihydroxyphenylserine (L-DOPS) versus placebo (an inactive substance that looks like study drug) in addition to other Parkinson Disease (PD) drugs will improve balance, walking, and reduce risk of falls and/or severity of falls in PD subjects. The study is also being done to determine the effectiveness, safety, and tolerability of L-DOPS, and whether it will decrease Freezing of Gait (FOG), improve apathy (generalized disinterest) or show a relationship between apathy and slowed movement and fall risk.

Collaborators: Dr. Abe Lieberman

Funding Sources


St. Joseph's Hospital